About the Multidisciplinary Seminar Program

Created in 1995, the Escola Tecnica Superior d'Enginyeria Quimica (ETSEQ) at Universitat Rovira i Virgili aims at becoming an international reference in chemical engineering education and research. The ETSEQ is located in an area that is socially and economically very dynamic, and that is home to one of the most important centers of chemical industry in southern Europe.

The Multidisciplinary Seminar Program is both the seminar series for faculty and researchers in the ETSEQ, and a mandatory class for its graduate students. The Program aims at inviting leading international researchers working on areas that are of interest to faculty and researchers in the School.

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Next seminar (April 27, 2018)

X-ray crystallography as a tool for analysis of protein/aptamer complexes (Rafal Dolot)

Location: Sala de Graus, ETSEQ
Start time: 12 p.m.

Abstract:

Hydrophobic and hydrogen bonding interactions have long been recognized as a fundamental driving force behind macromolecular stability and complex formation. Therefore, such interactions between nucleic acid bases and amino acids play a key role in the sequence-specific recognition of a nucleic acid by a protein in biological systems. This is also the case for interactions between an in vitro selected nucleic acid aptamer and its protein target. Numerous crystal structures show that hydrophobic interactions mainly occur between pyrimidine bases and the side chains of certain hydrophobic amino acids such as the indole ring of tryptophan. However, relatively little is known about engineering DNA-protein interactions to improve complex stability. X-ray crystallography analysis of crystallized protein/aptamer complexes will give valuable data to understanding process of molecules recognition, to design aptamers modification for increasing their specificity and affinity.

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April 2018

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May 2018

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