About the Multidisciplinary Seminar Program
Created in 1995, the Escola Tecnica Superior d'Enginyeria Quimica (ETSEQ) at Universitat Rovira i Virgili aims at becoming an international reference in chemical engineering education and research. The ETSEQ is located in an area that is socially and economically very dynamic, and that is home to one of the most important centers of chemical industry in southern Europe.
The Multidisciplinary Seminar Program is both the seminar series for faculty and researchers in the ETSEQ, and a mandatory class for its graduate students. The Program aims at inviting leading international researchers working on areas that are of interest to faculty and researchers in the School.Learn more
Next seminar (April 7, 2017)
Location: Sala de Graus, ETSEQ
Start time: 12 p.m.
The assembly of normally soluble proteins into long fibrils, known as amyloids, is associated with a range of pathologies, including Alzheimer’s and Parkinson’s diseases. A large number of structurally unrelated proteins form this type of fibrils, and we are in a pursuit of physical principles that underlie the amyloid formation and propagation.
We show that small disorders oligomers, which are increasingly believed to be the prime cause for cellular toxicity, serve as nucleation centers for the fibril formation. We then relate experimentally measurable kinetic descriptors of amyloid aggregation to the microscopic mechanisms of the process.
Once formed, amyloid fibrils can catalyse the formation of new oligomers and
fibrils in a process that resembles self-replication. By combining simulations with biosensing and kinetic measurements of the aggregation of Alzheimer’s peptide, we propose a mechanistic explanation for the self-replication of protein fibrils, and discuss its thermodynamic signature. Finally, we consider the design of possible inhibitors of the fibril self-replication process. Mechanistic understandings provided here not only have implications for future efforts to control pathological protein aggregation, but are also of interest for the rational assembly of bionanomaterials, where achieving and controlling self-replication is one of the unfulfilled goals.
(See full abstract on the attachment)
- April 21, 2017 - TBA (Benjamin Thiria )
- April 28, 2017 - TBA (Iwona Gulaczyk)
- May 5, 2017 - Laser printing of biomaterials, microorganisms, and living cells (Boris N. Chichkov )
- May 12, 2017 - SERS-based sensors of proteins involved in cancer (Elena Pazos Chantrero)
Monthly seminar index